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Low-intensity pulsed ultrasound (LIPUS) has gained attention for its potential role in periodontal regeneration and healing.This systematic review and meta-analysis aim to assess the efficacy of LIPUS in periodontal therapy by evaluating clinical and preclinical studies.The findings suggest that LIPUS enhances periodontal tissue regeneration by stimulating angiogenesis, reducing inflammatory cytokines and promoting osteoblast differentiation.Additionally, LIPUS facilitates extracellular matrix production and accelerates bone remodeling, making it a promising adjunct in periodontal treatment.Meta-analysis data indicate a significant improvement in clinical attachment level (CAL), probing depth (PD) reduction and alveolar bone regeneration with LIPUS application.However, variability in study protocols, sample sizes and treatment parameters calls for further well-designed trials to confirm its clinical benefits and establish standardized treatment guidelines.This review provides a comprehensive evaluation of the current literature, identifies gaps and suggests future research directions for integrating LIPUS into routine periodontal care.
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Neelam Das (2025) studied this question.
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