Key result
Isolated ultrafiltration significantly reduced extravascular lung water compared to no treatment, but superiority between ultrafiltration and furosemide could not be demonstrated.
Why the study?
Does furosemide or isolated ultrafiltration reduce extravascular lung water in mongrel dogs with oleic acid-induced pulmonary edema?
Does furosemide or isolated ultrafiltration reduce extravascular lung water in mongrel dogs with oleic acid-induced pulmonary edema?
In a canine model of pulmonary edema, isolated ultrafiltration reduced extravascular lung water compared to no treatment, but neither ultrafiltration nor furosemide demonstrated clear superiority over each other.
Answers are grounded in this paper and cite their sources.
Does not support clinical use of ultrafiltration over furosemide; leaves open its role in human pulmonary edema.
We studied the effects of no treatment, furosemide treatment, and isolated ultrafiltration on extravascular lung water (ETVL) in mongrel dogs in whom pulmonary edema was induced with oleic acid. In all treatment groups, ETVL was significantly elevated 90 min after oleic acid infusion. At 270 min, we found no difference between nontreatment and furosemide. There was, however, a significant difference between no treatment and ultrafiltration but not between furosemide and ultrafiltration. In spite of observations which suggest that ultrafiltration is of benefit in reducing ETVL, we could not demonstrate superiority of one therapy over another.
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Sivak et al. (1986) studied Oleic acid-induced pulmonary edema. Furosemide or isolated ultrafiltration vs. No treatment was evaluated on Extravascular lung water (ETVL). Isolated ultrafiltration significantly reduced extravascular lung water compared to no treatment, but superiority between ultrafiltration and furosemide could not be demonstrated.
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