Key result
Anticoagulation in pregnant patients with prosthetic heart valves shows manageable maternal risk without substantial perinatal mortality.
Why the study?
The safety and management of pregnancy following insertion of cardiac valve prostheses, including anticoagulant use, required further evaluation.
Is pregnancy safe in patients with prosthetic heart valves on anticoagulant therapy?
Population
31 patients with prosthetic heart valves and 35 pregnancies
Comparison
Use of long-acting oral anticoagulants antenatally versus heparin during labour
Design
Review and case report
Authors
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Supports individualized counseling for pregnancy in prosthetic valve patients; leaves open need for contemporary prospective data on anticoagulation.
Is pregnancy safe in patients with prosthetic heart valves on anticoagulant therapy?
Pregnancy in women with prosthetic heart valves is feasible and not an unacceptable hazard, with a suggested anticoagulation strategy of oral anticoagulants antenatally and heparin during labor.
H. N. Macdonald (1970) conducted a review in Pregnancy with prosthetic heart valves (n=31). Pregnancy with prosthetic heart valves was evaluated on Maternal hazard and perinatal mortality. Pregnancy in patients with prosthetic heart valves does not pose an unacceptable hazard, and despite frequent anticoagulant use, perinatal mortality is not greatly increased.
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