Key result
Non-constricting perivascular cuff placement increases carotid intimal area ~7-fold compared to control.
Why the study?
The haemodynamic effects of a non-constricting silastic cuff on the rabbit common carotid artery and its relation to intimal thickening were investigated.
Absolute Event Rate: 0.098% vs 0.014%
p-value: p=<0.025
In the Moncada model of atherosclerosis, a non-constricting silastic cuff causes kinking, vasoconstriction, and altered blood flow velocity, which may explain the resulting intimal thickening.
Cuff-induced carotid kinking and flow changes may promote intimal thickening in rabbits; leaves open relevance to human restenosis.
The application of a non-constricting silastic cuff to the rabbit common carotid artery (CCA; n = 5) results in intimal thickening within 7 days. 2. Ultrasonography showed kinking of the CCA at the cuff edges, as well as a 13% arterial narrowing (P less than 0.02) within the cuffed segment, both at days 1 and 7. Correspondingly, the time averaged diastolic Doppler velocity (TAV) was 68.8 +/- 12.8% higher (P less than 0.025) in the cuffed region in comparison with that 1 cm proximal (P 1 cm) on day 1, and 54.2 +/- 11.5% higher at day 7 (P less than 0.05). TAV values along control silastic strips were not significantly changed. 3. There was a significant increase (P less than 0.025) in intimal area within the cuffed region (0.098 +/- 0.024 mm3) compared with both the proximal control (0.014 +/- 0.001 mm3) and with that over control silastic strips (0.021 +/- 0.004 mm3, P less than 0.01). 4. Medial area within the cuff (0.433 +/- 0.017 mm3) was decreased (P less than 0.005) compared with P 1 cm control (0.602 +/- 0.069 mm3). 5. There was gross peri-arteritic thickening involving the adventitia along the non-constricted cuffed segment. Importantly, it was also noted alongside the control silastic strip. 6. Kinking of the CCA and associated vasoconstriction cause changes in blood flow velocity along even a non-constricting cuff, and this may explain the intimal thickening previously noted in this experimental model. The peri-arteritic changes, on the other hand, appear to be a reaction to the silastic itself.
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Yong et al. (1992) studied Atherosclerosis model (n=5). Non-constricting silastic cuff vs. Proximal control and control silastic strips was evaluated on Intimal area within the cuffed region (p=<0.025). Application of a non-constricting silastic cuff to the rabbit common carotid artery significantly increased intimal area compared to proximal control (0.098 vs 0.014 mm3, P<0.025).
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