Key result
FTO rs9939609 A allele is linked to worse glycemic control and adiponectin levels in obese diabetic women.
Why the study?
The association of the rs9939609 polymorphism of the FTO gene with adiposity indexes, type 2 diabetes mellitus, and adiponectin level in Iranian obese women was unclear.
Does the FTO rs9939609 polymorphism correlate with adiponectin levels and metabolic parameters in obese type 2 diabetic women?
Population
83 obese Iranian women
Comparison
Mutant A allele vs wild type genotype of FTO rs9939609
Design
Case-control study
Authors
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FTO rs9939609 variant was associated with adverse metabolic parameters in obese diabetic Iranian women; hypothesis-generating and should not yet change practice.
Case-Control (n=83)
Does the FTO rs9939609 polymorphism correlate with adiponectin levels and metabolic parameters in obese type 2 diabetic women?
The FTO rs9939609 polymorphism is associated with adverse metabolic parameters and adiponectin levels in obese Iranian women with type 2 diabetes.
Shool et al. (2017) conducted a case-control in Obesity and type 2 diabetes mellitus (n=83). FTO rs9939609 polymorphism (mutant A allele) vs. Wild type genotype was evaluated on Association of FTO rs9939609 polymorphism with adiposity indexes, T2DM, and adiponectin level. The FTO rs9939609 mutant A allele was significantly associated with fasting blood sugar, HbA1c, triglycerides, insulin resistance, and adiponectin levels in obese diabetic women.
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