Key result
High-resolution mapping localizes the renal pelvis pacemaker to the pelvicalyceal border with slow, inhomogeneous conduction.
Why the study?
The precise location and conduction pathways of the pacemaker in the isolated renal pelvis were not well characterized.
Population
Renal pelvis preparations isolated from sheep
Design
Electrophysiological study using simultaneous recordings from 240 extracellular electrodes
Authors
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Pelvic pacemaker mapping in isolated sheep tissue warrants no clinical change; leaves open translation to human pyeloureteral physiology pending in vivo studies.
High-resolution mapping of the isolated sheep renal pelvis reveals that pacemaking originates at the pelvicalyceal border and conduction is characterized by inhomogeneities and blocks independent of refractory periods.
Lammers et al. (1996) studied this question. High-resolution electrophysiological mapping was evaluated on Location of the pacemaker and pathway of conduction. High-resolution mapping of the isolated sheep renal pelvis revealed that the pacemaker is located at the pelvicalyceal border, with slow, inhomogeneous conduction and instances of conduction block.
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