Key result
Systemic lupus erythematosus was associated with significantly impaired cardiac autonomic functions compared to healthy controls, including lower HRR3 (52.8 vs 65.8, p<0.001) and greater QT dispersion.
Why the study?
Cardiovascular involvement is a leading cause of death in systemic lupus erythematosus, but cardiac autonomic functions in SLE patients are not well characterized.
Are cardiac autonomic functions impaired in patients with systemic lupus erythematosus compared to healthy controls?
Case-Control (n=68)
Are cardiac autonomic functions impaired in patients with systemic lupus erythematosus compared to healthy controls?
Patients with systemic lupus erythematosus exhibit impaired cardiac autonomic function and increased QT dispersion even in the absence of overt cardiac symptoms, suggesting a potential mechanism for increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for autonomic dysfunction in SLE CV risk; prospective studies needed before clinical adoption.
BACKGROUND: Cardiovascular involvement is one of the leading causes of death among patients with systemic lupus erythematosus (SLE). In this study, we aimed to investigate cardiac autonomic functions in SLE patients. METHODS: We enrolled 36 patients (25 female; mean age 34.2 ± 10.2 years) with SLE and 32 healthy subjects (23 female; mean age 35.0 ± 10.3 years). All participants underwent 24-h Holter recording. Heart rate recovery (HRR) indices were calculated by subtracting first, second, and third-minute heart rates from maximal heart rate. All patients underwent heart rate variability (HRV), heart rate turbulence (HRT) and QT dispersion analysis. The mean SLE duration was 8.4 ± 4.0 years. RESULTS: According to the baseline demographic characteristics, both groups were similar with regard to age, gender, body mass index and left ventricular ejection fraction. Mean HRR1 (32.6 ± 10.9 vs. 42.5 ± 6.5, p = 0.038), HRR2 (51.0 ± 16.9 vs. 61.0 ± 10.8, p = 0.01) and HRR3 (52.8 ± 17.5 vs. 65.8 ± 9.8, p < 0.001) values were significantly higher in control group. When HRV was considered, SDNN, SDANN, RMSSD, PNN50 and high frequency (HF) component were significantly decreased in patients with SLE compared with healthy controls, but low frequency (LF) component and LF/HF were significantly higher in SLE patients. In addition, HRT onset and HRT slope values were significantly less negative in SLE patients. QT dispersion was significantly greater in SLE patients than healthy subjects (81.3 ± 15.8 vs. 53.2 ± 13.1, p < 0.001). CONCLUSION: Our study results suggest that cardiac autonomic functions are impaired in SLE patients despite the absence of overt cardiac involvement and symptoms. Further studies are needed to elucidate the prognostic significance and clinical implications of impaired autonomic functions in patients with SLE.
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Yorgun et al. (2011) conducted a case-control in Systemic lupus erythematosus (n=68). Systemic lupus erythematosus vs. Healthy subjects was evaluated on Heart rate recovery at 3 minutes (HRR3) (p=<0.001). Systemic lupus erythematosus was associated with significantly impaired cardiac autonomic functions compared to healthy controls, including lower HRR3 (52.8 vs 65.8, p<0.001) and greater QT dispersion.
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