Key result
SLE is linked to ~46% lower SDNN compared to healthy controls.
Why the study?
Cardiac autonomic function and heart rate variability have not been well characterized in patients with systemic lupus erythematosus without clinical dysautonomia.
Do patients with systemic lupus erythematosus without clinical dysautonomia have impaired heart rate variability compared to healthy controls?
Population
23 SLE patients without clinical dysautonomia and 14 healthy controls
Comparison
SLE patients vs healthy volunteer subjects
Design
Case-control study
Authors
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SLE may indicate subclinical autonomic dysfunction without overt symptoms; leaves open whether HRV monitoring improves outcomes or risk stratification.
Case-Control (n=37)
Do patients with systemic lupus erythematosus without clinical dysautonomia have impaired heart rate variability compared to healthy controls?
Absolute Event Rate: 69.4% vs 127.72%
Patients with systemic lupus erythematosus without clinical dysautonomia exhibit significantly reduced heart rate variability, indicating subclinical cardiac autonomic dysfunction.
Laganà et al. (1996) conducted a case-control in Systemic Lupus Erythematosus (n=37). Systemic Lupus Erythematosus vs. Healthy volunteers was evaluated on Standard deviation of the RR intervals average (SDNN). Systemic Lupus Erythematosus was associated with significantly lower heart rate variability compared to healthy controls, including a reduced SDNN (69.40 vs 127.72).
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