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September 2, 2016Arthritis Research & TherapyOpen Access

Baseline HRV parameters were inversely related to disease activity and flare, and changes in RMSSD between visits were inversely related to changes in SLEDAI (p = 0.007).

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Why the study?

Is heart rate variability associated with disease activity and cytokine levels in patients with systemic lupus erythematosus?

Population

53 patients with systemic lupus erythematosus (SLE) from the Oklahoma Lupus Cohort

Design

Cohort

Follow-up

Two visits

Authors

ATAikaterini ThanouSSStavros StavrakisJDJohn Dyer

Discussion

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Member takes

Overview

May support HRV monitoring of SLE activity; hypothesis-generating and should not yet change practice.

Structured PICO

Is heart rate variability associated with disease activity and cytokine levels in patients with systemic lupus erythematosus?

P
Population
53 patients with systemic lupus erythematosus (SLE) from the Oklahoma Lupus Cohort
I
Intervention
Heart rate variability (HRV) assessment via 5-minute electrocardiogram
O
Outcome
Relationship of HRV with SLE disease activity (SLEDAI, BILAG, PGA, Flare Index) and selected cytokine pathwayssurrogate

Impaired heart rate variability is associated with increased lupus disease activity and elevated levels of cytokines related to IFN type II and TNF pathways.

Cite This Study

Thanou et al. (2016) studied this question.

synapsesocial.com/papers/6a8939d1d76717fba3eb1698https://doi.org/10.1186/s13075-016-1087-x
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