Key result
Exercise capacity variables predict survival and clinical stability in idiopathic PAH better than in associated PAH.
Why the study?
The ability of exercise testing to predict survival and time to clinical worsening in idiopathic versus associated pulmonary arterial hypertension was unclear.
Do cardiopulmonary exercise testing and 6-minute walk test variables predict survival and time to clinical worsening in patients with idiopathic versus associated pulmonary arterial hypertension?
Population
136 patients with PAH (85 idiopathic, 51 associated)
Comparison
Idiopathic PAH versus associated PAH
Design
Cohort study with cardiopulmonary exercise testing and 6-min walk test
Authors
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Exercise variables may aid risk stratification in idiopathic PAH; leaves open incremental value and utility in associated forms.
Cohort (n=136)
Do cardiopulmonary exercise testing and 6-minute walk test variables predict survival and time to clinical worsening in patients with idiopathic versus associated pulmonary arterial hypertension?
Exercise testing variables (6-minute walk distance, VE/VCO2, and peak VO2) are useful predictors of survival and clinical stability in idiopathic PAH, but lack independent predictive value in associated PAH.
Deboeck et al. (2012) conducted a cohort in Idiopathic versus associated pulmonary arterial hypertension (n=136). Cardiopulmonary exercise testing and 6-min walk test was evaluated on Survival and time to clinical worsening. Exercise variables predicted survival and clinical stability in idiopathic PAH (cut-offs: 305 m for 6-min walk, 54 for V'(E)/V'(CO(2),at)), but were less accurate predictors in associated PAH.
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