Key result
Pelvicalyceal border smooth muscle generates spontaneous periodic action potentials with resting potentials around ~42 mV.
Why the study?
The existence and characteristics of pacemaker activity at the pelvicalyceal border were not previously demonstrated by intracellular recordings.
Population
Smooth muscle from guinea pig pelvicalyceal border
Design
Intracellular glass microelectrode recording study
Authors
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Does not alter clinical practice; confirms pacemaker activity in this model but leaves open human translational relevance.
Intracellular microelectrode recordings confirm the presence of pacemaker activity at the guinea pig pelvicalyceal border.
Tsuchida et al. (2010) studied this question. Intracellular glass microelectrode recording was evaluated on Spontaneous action potentials (slow waves) characteristics. Intracellular glass microelectrode recordings of guinea pig pelvicalyceal border smooth muscle demonstrated periodic spontaneous action potentials with a resting potential of 42.3 +/- 1.1 mV.
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