Key result
Mean pulmonary capillary wedge pressure showed excellent correlation with mean left atrial pressure before (r=0.95, P<0.001) and after balloon mitral valvotomy.
Why the study?
The correlation between pulmonary capillary wedge pressure and left atrial pressure and their transmitral gradients in mitral stenosis patients undergoing balloon mitral valvotomy was not well established.
Cohort (n=30)
Effect estimate: r=0.95
p-value: p=<0.001
PCWP shows excellent correlation with LAP and can be reliably used to measure transmitral gradients in patients with mitral stenosis undergoing balloon valvotomy.
AIMS: We sought to evaluate the correlation between PCWP and LAP and to compare transmitral gradients obtained with LAP and PCWP in MS, before and after balloon mitral valvotomy (BMV). METHODS: Consecutive patients with MS for BMV were included in this prospective cohort study. Simultaneous PCWP and LAP were recorded followed by simultaneous left atrium-left ventricular (LA-LV) and pulmonary capillary wedge pressure-left ventricular (PCWP-LV) gradients before and after BMV. RESULTS: There were 30 patients with a mean age of 41 yrs (males 10 (33.3%), females 20 (66.7%)). There was no significant difference between mean LAP and mean PCWP before BMV (21.3mmHg and 22.3mmHg, respectively) or after BMV (15.3mmHg and 17.3mmHg, respectively). There was excellent correlation between mean PCWP and mean LAP before BMV (r=0.95) (p<0.001) and after BMV (r=0.85) (p<0.001). The phasic components of the pressures (a and v waves) of LAP and PCWP also showed good correlation before and after BMV. Further, transmitral gradients assessed by LA-LV and PCWP-LV pressures showed excellent correlation before BMV (r=0.95) (p<0.001) and after BMV (r=0.95) (p<0.001). CONCLUSION: In patients with MS undergoing balloon valvotomy, PCWP shows good correlation with LAP. Transmitral gradients obtained with PCWP and LAP also correlate well after correction of phase lag in PCWP tracing. Hence, PCWP can be used for reliable measurement of transmitral gradient.
No takes yet. Share an insight, caveat, or question.
Vinayakumar et al. (2016) conducted a cohort in Mitral stenosis (n=30). Pulmonary capillary wedge pressure (PCWP) vs. Left atrial pressure (LAP) was evaluated on Correlation between mean PCWP and mean LAP before BMV (r=0.95, p=<0.001). Mean pulmonary capillary wedge pressure showed excellent correlation with mean left atrial pressure before (r=0.95, P<0.001) and after balloon mitral valvotomy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: