Key result
Isoelectric focusing-antigen overlay (IEF-O) successfully identified herpes simplex virus-1 glycoprotein B as the target of cerebrospinal fluid oligoclonal bands in a patient with HBE.
Why the study?
Does the isoelectric focusing-antigen overlay (IEF-O) technique improve the diagnosis of herpetic brainstem encephalitis compared to conventional immunovirological studies in an adult patient?
Case Report (n=1)
Does the isoelectric focusing-antigen overlay (IEF-O) technique improve the diagnosis of herpetic brainstem encephalitis compared to conventional immunovirological studies in an adult patient?
The isoelectric focusing-antigen overlay (IEF-O) technique may represent a useful support for the in vivo diagnosis of herpetic brainstem encephalitis when conventional studies fail.
May support herpetic brainstem encephalitis diagnosis when conventional tests fail; leaves open validation in prospective cohorts.
We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
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Martino et al. (2009) conducted a case report in Herpetic brainstem encephalitis (n=1). Isoelectric focusing-antigen overlay (IEF-O) technique vs. Conventional immunovirological studies was evaluated on Detection of specific anti-HSV immunoresponse restricted to the CNS. Isoelectric focusing-antigen overlay (IEF-O) successfully identified herpes simplex virus-1 glycoprotein B as the target of cerebrospinal fluid oligoclonal bands in a patient with HBE.
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