Key result
Multiple system atrophy is linked to significantly lower HRV, tracking disease duration and severity.
Why the study?
The usefulness of heart rate variability parameters for evaluating cardiac autonomic dysfunction in multiple system atrophy patients was investigated.
Does heart rate variability assessment identify cardiac autonomic dysfunction in patients with multiple system atrophy compared to normal controls?
Case-Control (n=44)
Does heart rate variability assessment identify cardiac autonomic dysfunction in patients with multiple system atrophy compared to normal controls?
Heart rate variability parameters are significantly reduced in multiple system atrophy and correlate with disease severity, suggesting utility in evaluating cardiac autonomic dysfunction.
BACKGROUND: The purpose of this study was to investigate whether heart rate variability parameters can be useful for evaluating cardiac autonomic dysfunction in multiple system atrophy patients. METHODS: Both the time and frequency domains of heart rate variability were investigated among 17 multiple system atrophy patients and 27 normal control subjects. RESULTS: All time- and frequency-domain measures, except the low- to high-frequency ratio, were significantly lower in multiple system atrophy patients than in controls. In multiple system atrophy patients, there were significant inverse correlations between heart rate variability parameters and disease duration, as well as disease severity, but heart rate variability parameters were not affected by other autonomic dysfunctions. CONCLUSIONS: The cardiac autonomic state of multiple system atrophy was characterized by decreases in both sympathetic and parasympathetic tones. Because heart rate variability parameters were not affected by other autonomic dysfunctions, this may be a useful method for evaluating cardiac autonomic dysfunction in multiple system atrophy.
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Furushima et al. (2012) conducted a case-control in Multiple system atrophy (n=44). Multiple system atrophy vs. Normal control subjects was evaluated on Time and frequency domains of heart rate variability. Heart rate variability parameters were significantly lower in patients with multiple system atrophy compared to normal controls, and inversely correlated with disease duration and severity.
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