Key result
Surgical resection and histopathology confirm rare primary cardiac leiomyosarcoma in prior malignancy.
Why the study?
Primary cardiac leiomyosarcomas are exceedingly rare malignancies that present insidiously and are often diagnosed late due to nonspecific symptoms.
Case Report (n=1)
This case report highlights a rare presentation of primary cardiac leiomyosarcoma in a patient with prior extra-cardiac malignancies.
Supports histopathology for cardiac masses with prior leiomyoma; leaves open evidence-based management strategies.
Primary cardiac leiomyosarcomas are exceedingly rare malignancies. They present insidiously with symptoms often attributed to mass effect or obstruction of blood flow, leading to delayed diagnosis. We present a rare case of primary cardiac leiomyosarcoma with a history of exophytic leiomyoma. This is a primary cardiac tumor interestingly in a patient with a history of extra-cardiac malignancies. Histopathological confirmation is crucial for timely diagnosis and appropriate management. Aggressive surgical resection remains the mainstay of treatment, but the high recurrence rates necessitate ongoing surveillance and consideration of adjuvant therapies.
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Tuonuur et al. (2025) conducted a case report in Primary atrial leiomyosarcoma (n=1). Surgical resection was evaluated. A rare case of primary cardiac leiomyosarcoma was identified in a patient with a history of extra-cardiac malignancies, highlighting the importance of histopathological confirmation and surgical resection.
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