Key result
Visible Heart methodologies enhance preclinical design and testing of novel cardiac valve therapies.
Why the study?
Significant improvements in cardiac imaging and understanding of valvular anatomies have been pivotal to advances in valve repair and replacement therapies.
The Visible Heart(R) methodologies provide a valuable ex vivo platform for imaging and evaluating novel cardiac valve repair and replacement therapies.
In recent years huge strides have been made in the fields of interventional cardiology and cardiac surgery which now allow physicians and surgeons to repair or replace cardiac valves with greater success in a larger demographic of patients. Pivotal to these advances has been significant improvements in cardiac imaging and improved fundamental understanding of valvular anatomies and morphologies. We describe here a novel series of techniques utilized within the Visible Heart(®) laboratory by engineers, scientists, and/or anatomists to visualize and analyze the form and function of the four cardiac valves and to assess potential repair or replacement therapies. The study of reanimated large mammalian hearts (including human hearts) using various imaging modalities, as well as specially prepared anatomical specimens, has enhanced the design, development, and testing of novel cardiac therapies.
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Bateman et al. (2012) conducted a review in Cardiac valve repair and replacement. Visible Heart(®) methodologies was evaluated. The Visible Heart methodologies, utilizing reanimated mammalian and human hearts with various imaging modalities, enhance the design, development, and testing of novel cardiac valve therapies.
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