Key result
Marek's disease virus evolution toward greater virulence occurs in both susceptible and resistant MHC haplotypes, but the resulting increase in pathogenicity is constrained by the resistant MHC haplotype.
Population
Resistant (MHC-B21) and susceptible (MHC-B13) Line 0 chickens
Design
Preclinical
Follow-up
21 days after challenge
Authors
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Supports breeding resistant MHC haplotypes to limit MDV virulence; leaves open generalizability to other hosts or pathogens.
Marek's disease virus evolution toward greater virulence occurs in both susceptible and resistant MHC haplotypes, but the resulting increase in pathogenicity is constrained by the resistant MHC haplotype.
Hunt et al. (2013) studied Marek's disease. In vivo passage of Md5B40BAC virus vs. MHC-B13 vs MHC-B21 lines was evaluated on Marek's disease virulence/pathology. Marek's disease virus evolution toward greater virulence occurs in both susceptible and resistant MHC haplotypes, but the resulting increase in pathogenicity is constrained by the resistant MHC haplotype.
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