Key result
Large-scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, highlighting its complex genetic architecture.
This review summarizes 15 years of genetic discoveries in multiple sclerosis, highlighting over 230 identified risk effects.
MS genetic discoveries accumulate; leaves open translation to aetiological framework and clinical actionability.
Large-scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, making it a prototypical common disease with complex genetic architecture. Here, after a brief historical background on the discovery and definition of the disease, we summarise the last fifteen years of genetic discoveries and map out the challenges that remain to translate these findings into an aetiological framework and actionable clinical understanding.
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Cotsapas et al. (2018) conducted a review in Multiple sclerosis. Large-scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, highlighting its complex genetic architecture.
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