Key result
High right atrial neurostimulation directly correlates with acute sinus cycle length and heart rate changes.
Why the study?
High resting heart rates are an independent risk factor for higher overall mortality, and intracardiac neurostimulation targeting parasympathetic tone in the high right atrium may modulate heart cycle length.
Does intracardiac electrical neurostimulation in the high right atrium modulate sinus cycle length and ventricular heart rate in patients undergoing ablation?
Does intracardiac electrical neurostimulation in the high right atrium modulate sinus cycle length and ventricular heart rate in patients undergoing ablation?
Intracardiac electrical neurostimulation in the high right atrium can acutely modulate sinus cycle length and heart rate during ablation procedures.
May lower heart rate via sinoatrial neurostimulation; leaves open safety, durability, and outcome benefit in prospective trials.
Today, high resting heart rates are known to be an independent risk factor for a higher overall mortality, irrespective of underlying coronary diseases. Neurostimulation is a fast growing, wide spread approach to treat various disorders by electrical stimulation of specific nerve cells. We present a technique of intracardiac neurostimulation to the parasympathetic tone in the high right human atrium in the sinoatrial node area. Investigations include recording the decreasing effects of heart rate, the anatomical endocardial visualization of the right atrium, and developing gradient maps with parasympathetic and sympathetic nerve bundles. During an ablation procedure within the sinus rhythm, patients are stimulated with a bipolar electrode catheter which can be detected by an electroanatomical navigation system. Sinus cycle length and corresponding ventricular heart rate are recorded before, during and after stimulation and show a direct correlation with the start and end of stimulation.
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Pohl et al. (2013) studied Patients undergoing an ablation procedure. Intracardiac neurostimulation in the high right human atrium vs. Before and after stimulation was evaluated on Sinus cycle length and corresponding ventricular heart rate. Intracardiac neurostimulation in the high right human atrium directly correlated with changes in sinus cycle length and ventricular heart rate during ablation procedures.
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