What is the clinical evidence from this study?

Study design: Observational. Population: Familial Hypercholesterolaemia. Intervention: Nurse-led family tracing (cascade testing). Primary outcome: Participation rate, diagnostic yield, and cost.

What does this research mean for the field?

Nurse-led family tracing for familial hypercholesterolaemia achieves approximately 70% participation among index cases and identifies 30% of tested relatives as likely having FH at an average cost of £500 per relative. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 22, 2008Annals of Clinical Biochemistry International Journal of Laboratory Medicine

Family tracing to identify patients with Familial Hypercholesterolaemia: the second Audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project

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Key result

Nurse-led cascade testing identifies FH in ~30% of tested relatives, with high patient participation.

Why the study?

Family tracing led by FH Nurses is recognized to find new FH patients, but acceptability, feasibility, and costs in the UK needed evaluation.

Is nurse-led family tracing for familial hypercholesterolaemia feasible, acceptable, and cost-effective?

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Is nurse-led family tracing for familial hypercholesterolaemia feasible, acceptable, and cost-effective?

Population

Patients with familial hypercholesterolaemia and their relatives across five NHS Trusts participating in a nurse-led family tracing project.

Exposure

Family tracing (cascade testing) led by FH Nurses

Outcome

Acceptability to patients, feasibility, and costs of family tracing

Nurse-led cascade testing for familial hypercholesterolaemia is feasible and acceptable, but national implementation requires integrated infrastructure to ensure access.

Limitations

Uncertainty of a diagnosis based on lipid measurements
34% of relatives lived outside the catchment area and could not attend the clinics
Lower participation when patients had been discharged from clinics and in metropolitan areas
Uncertainty of diagnosis based on lipid measurements
Lower participation in metropolitan areas and among discharged patients
34% of relatives lived outside catchment area and could not attend clinics

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports nurse-led FH family tracing feasibility; leaves open scalable national implementation without integrated infrastructure.

Cite This Study

Hadfield et al. (2008) conducted an observational in Familial Hypercholesterolaemia. Nurse-led family tracing (cascade testing) was evaluated on Participation rate, diagnostic yield, and cost. Nurse-led family tracing for familial hypercholesterolaemia achieved ~70% participation among index cases and identified 30% of tested relatives as likely having FH, costing £500 per relative.

synapsesocial.com/papers/6ab4daeb4883eaa6f5df702d https://doi.org/10.1258/acb.2008.008094

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Family tracing to identify patients with Familial Hypercholesterolaemia: the second Audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Family tracing to identify patients with Familial Hypercholesterolaemia: the second Audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider