Key result
Perioperative n-3 PUFA intake significantly reduced length of hospital stay (MD -2.47 days; 95% CI -3.25 to -1.69) and postoperative infectious complications (RR 0.66; 95% CI 0.49-0.87) compared to conventional nutrition.
Why the study?
Does n-3 PUFA intake reduce LOS, SIRS duration, CRP levels, and postoperative complications in abdominal cancer surgical patients compared to conventional nutrition?
Systematic Review
Does n-3 PUFA intake reduce LOS, SIRS duration, CRP levels, and postoperative complications in abdominal cancer surgical patients compared to conventional nutrition?
Mean Difference: -2.47 (95% CI -3.25–-1.69)
Perioperative n-3 PUFA nutritional support significantly reduces postoperative infectious complications, length of hospital stay, and systemic inflammation in gastrointestinal cancer surgical patients.
Supports perioperative n-3 PUFA to cut infections, LOS, and SIRS in GI cancer surgery; reinforces RCT meta-evidence for immunonutrition.
This study was a systematic evaluation of the beneficial effects of n-3 polyunsaturated fatty acid (PUFA) in abdominal cancer surgical patients. A literature search of the databases PubMed, Medline, Cochrane, and EMBASE was conducted for studies published up to November 2014 in English language journals. Randomized controlled trials (RCTs) examining the effects of n-3 PUFA intake relative to conventional nutrition in surgical patients were included. The main outcomes were the duration of systemic inflammatory response syndrome (SIRS), length of hospital stay (LOS), serum C-reactive protein (CRP) levels, and postoperative complications. We identified 15 RCTs among 158 relevant trials. The results indicated the associations between n-3 PUFA intake and reduced LOS [mean differences (MDs), -2.47 d; 95% confidence intervals (CIs), -3.25 to -1.69], duration of SIRS (MD, -0.57 d; 95% CI, -0.92 to -0.22), and serum CRP levels (MD, -3.97 mg/l; 95% CI, -7.88 to -0.07) compared with consumption of conventional nutrition, as well as reduced incidence of postoperative infectious complications (risk ratio, 0.66; 95% CI, 0.49-0.87). This systematic evaluation suggests that n-3 PUFA significantly reduces the postoperative infectious complication rate, and shortens hospitalization and SIRS duration, particularly in malnourished gastrointestinal cancer patients.
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Ma et al. (2016) conducted a systematic review in Gastrointestinal/abdominal cancer requiring surgery. n-3 polyunsaturated fatty acid (PUFA) nutritional support vs. Conventional nutrition was evaluated on Length of hospital stay (LOS) (MD -2.47, 95% CI -3.25 to -1.69). Perioperative n-3 PUFA intake significantly reduced length of hospital stay (MD -2.47 days; 95% CI -3.25 to -1.69) and postoperative infectious complications (RR 0.66; 95% CI 0.49-0.87) compared to conventional nutrition.