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November 12, 2025Nutrition ReviewsOpen Access

Effects of Preoperative Immunonutrition on Postoperative Complications in Patients Undergoing Colorectal Cancer Resection: A Systematic Review and Meta-analysis

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Authors

AOAndrea Orellana-JaenUniversidad de GranadaPCPablo CorresUniversity of the Basque CountryJOJesús Orellana-Jaén

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Overview

Systematic review reveals immunonutrition lowers minor infectious complications in colorectal cancer, indicating potential benefits of higher doses.

Key Points

  • Significant reductions in minor infectious complications were observed post colorectal cancer resection with immunonutrition.
  • The meta-analysis showed a risk ratio of 0.67 for minor infectious complications, indicating a substantial benefit.
  • Assessment involved randomized controlled trials and systematic review across 10 studies examining immunonutrition effects.
  • This highlights the need for consistent dosing in immunonutrition for enhanced patient outcomes post-surgery.

Cite This Study

Orellana-Jaen et al. (2025) studied this question.

synapsesocial.com/papers/6941adef0f5af7fd17df5feehttps://doi.org/10.1093/nutrit/nuaf276
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery: A Randomized Controlled Clinical Trial2024 · 8 citations
  2. 2Perioperative Immunonutrition in Gastrointestinal Oncology: A Comprehensive Umbrella Review and Meta-Analysis on Behalf of TROGSS—The Robotic Global Surgical Society2025 · 19 citations
  3. 3Perioperative nutrition therapy to optimize colorectal patient outcomes: A systematic review and meta‐analysis2026
  4. 4Effect of immunonutrition on surgery outcomes in cancer patients: evidence from an umbrella review on interventional and observational meta-analyses2026
  5. 5Preoperative immunonutrition and postoperative outcomes in patients with cancer undergoing major abdominal surgery: Retrospective cohort study2024 · 4 citations