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June 20, 2026BMC CancerOpen Access

Effect of immunonutrition on surgery outcomes in cancer patients: evidence from an umbrella review on interventional and observational meta-analyses

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Authors

HMHelia MardaniTehran University of Medical SciencesUKUlduz Riazi KhamenehIslamic Azad University of MarandAJAli JafariNational Nutrition and Food Technology Research Institute

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Overview

Umbrella review finds immunonutrition reduces complications in cancer surgery, suggesting improved recovery strategies.

Key Points

  • This review aims to assess how immunonutrition affects surgical outcomes in cancer patients.
  • Conducted an umbrella review of meta-analyses across MEDLINE/PubMed, SCOPUS, and WOS databases until September 2025.
  • Included 54 studies assessing immunonutrition's effects on various surgical outcomes.
  • Calculated pooled effect sizes and confidence intervals using a random-effects model.
  • RR = 0.79; 95% CI: 0.70–0.88 for overall postoperative complications.
  • HR = 0.86; 95% CI: 0.74–0.99 for mortality.
  • Postoperative intervention reduces overall complications (RR = 0.69; 95% CI: 0.54–0.89) and length of stay (2.26 days, P = 0.001).

Cite This Study

Mardani et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535f12https://doi.org/10.1186/s12885-026-15984-6
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