Key result
A complete preoperative immunonutrition regimen was associated with a significant reduction in in-hospital infectious complications (OR 0.54; 95% CI 0.31-0.98; p=0.044).
Why the study?
Preoperative malnutrition is a risk factor for postoperative complications in cancer patients undergoing surgical resection, leading researchers to evaluate the impact of preoperative immunonutrition on clinical outcomes.
Does a complete preoperative immunonutrition regimen reduce in-hospital infectious complications in patients with cancer undergoing major abdominal surgery?
Cohort (n=620)
Does a complete preoperative immunonutrition regimen reduce in-hospital infectious complications in patients with cancer undergoing major abdominal surgery?
Complete preoperative immunonutrition may reduce the risk of in-hospital infectious complications and critical care requirements in cancer patients undergoing major abdominal surgery.
Answers are grounded in this paper and cite their sources.
May lower postoperative infections after cancer surgery; hypothesis-generating and requires prospective confirmation before practice change.
BACKGROUND AND OBJECTIVES: Surgical resection is a first-line treatment for patients with cancer, but preoperative malnutrition is a risk factor for postoperative complications. This study aimed to evaluate the association between preoperative administration of an immunonutrition regimen and postoperative clinical outcomes in patients with cancer undergoing major abdominal surgery. METHODS: The Surgical Prehabilitation Multimodal Oncology (SUPREMO) retrospective cohort study, conducted from January 2021 to December 2023, included patients with cancer undergoing major abdominal surgery. Patients were categorized based on whether they received a complete immunonutrition regimen or an incomplete or no regimen. Demographic and clinical data were extracted from electronic health records for descriptive analysis. Logistic regression was used to assess the impact of immunonutrition on the risk of infectious complications, with clinical and demographic variables as explanatory factors. RESULTS: A total of 620 patients were included, with 49 % receiving a complete preoperative immunonutrition regimen. Bivariate analysis indicated that complete regimen administration was associated with lower intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and vasopressor support requirements (p = 0.005, p = 0.019, and p = 0.032, respectively). The logistic regression model showed a significant reduction in in-hospital infectious complications (odds ratio 0.54, 95 % confidence interval 0.31-0.98; p = 0.044). CONCLUSION: Administering a complete preoperative immunonutrition regimen may be associated with reduced infectious complications, ICU and IMV requirements, and vasopressor support use.
No takes yet. Share an insight, caveat, or question.
Chona et al. (2024) conducted a cohort in Cancer undergoing major abdominal surgery (n=620). Complete preoperative immunonutrition regimen vs. Incomplete or no immunonutrition regimen was evaluated on In-hospital infectious complications (OR 0.54, 95% CI 0.31-0.98, p=0.044). A complete preoperative immunonutrition regimen was associated with a significant reduction in in-hospital infectious complications (OR 0.54; 95% CI 0.31-0.98; p=0.044).
Synapse has enriched 10 related papers. Consider them for comparative context: