Key result
Torsion rheometry can be used to simulate and experimentally determine the dynamic acoustic properties of gelating gellan gum, converging within a standard deviation of ultrasound measurements.
Dynamic acoustic properties of gelating gellan gum can be simulated and experimentally determined using torsion rheometry, offering an alternative to brightness-mode ultrasound.
Rheometry offers an alternative for acoustic characterization of gels; leaves open in vivo validation and clinical translation.
Gellan gum is a hydrogel with several applications in ultrasonic imaging, novel drug delivery, and tissue regeneration. As hydrogels are dynamic entities, their viscocelastic and therefore their acoustic properties change over time, which is of interest to monitor. To determine the speed of sound from brightness-mode images, however, rather large quantities of hydrogel are needed. In this study, we investigated torsion rheometry as a means to determine acoustic properties. Perceived speeds of sound were derived and computed from torsion rheometry measurements of gelating gellan gum mixed with spermidine trihydrochloride crosslinker. For comparison, brightness-mode ultrasonic images were recorded of the same material inside a phantom well. The rheometry data converged to a speed of sound within a standard devitation of the speed of sound measured from the brightness-mode images.We have shown that dynamic acoustic properties of gelating gellan gum can be simulated and experimentally determined using torsion rheometry.
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Postema et al. (2022) studied this question. Torsion rheometry vs. Brightness-mode ultrasound was evaluated on Speed of sound. Torsion rheometry can be used to simulate and experimentally determine the dynamic acoustic properties of gelating gellan gum, converging within a standard deviation of ultrasound measurements.
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