Synthesis of Heterocycles Using Aminoacetals

h e r h e t e r o c y c l i c systems using t h e a c e t a l s i s given.The acetals of 2-aminoacetaldehyde ( I ) , u s u a l l y simply c a l l e d aminoacetals, are convenient synthons f o r p l a c i n g a C-C-N u n i t i n a molecule and have been used e x t e n s i v e l y i n h e t e r o c y c l i c chemistry.The e t h y l and methyl a c e t a l s a r e commercially a v a i l a b l e .The molecules have a nucleopnile, the nitrogen, a t one end and a blocked e l e c t r o p h i l e , t h e aldehyde a t the other.