The Effect of Pretreatment with Colchicine on the Inflammatory Response to Microcrystalline Urate

Article1 April 1965The Effect of Pretreatment with Colchicine on the Inflammatory Response to Microcrystalline UrateA Model for Gouty InflammationSTEPHEN E. MALAWISTA, M.D., J. E. SEEGMILLER, M.D.STEPHEN E. MALAWISTA, M.D., J. E. SEEGMILLER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-648 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNearly a century ago the British physician A. B. Garrod (1) regarded acute gouty arthritis as an inflammatory reaction to sodium urate crystals. Most investigators during the past three decades have denied such a role to sodium urate, largely because injected solutions or suspensions of sodium urate failed to produce an inflammatory reaction and because there was no consistent correlation between the degree of hyperuricemia and the development of acute gout (2-4).We have recently presented evidence to support Garrod's original hypothesis. By subcutaneous or intra-articular injection of microcrystals of monosodium urate in gouty and nongouty human volunteers, we produced...References1. GARROD AB: A Treatise on Gout and Rheumatic Gout: Rheumatoid Arthritis, 3rd ed. Longmans, Green & Co., London, 1876, p. 83. Google Scholar2. DE GRACIANSKY P: Recherches sur l'Acide Urique dans la Goutte, Theses, Paris, 1938, p. 102. Google Scholar3. HENCH PS: Gout and gouty arthritis, in Modern Medical Therapy in General Practice, Vol. 3, edited by BARR, D. P., Williams & Wilkins Co., Baltimore, 1940, p. 3359. Google Scholar4. GUTMANYU ABTF: Gout, a derangement of purine metabolism. Advances Intern. Med. 5: 227, 1952. MedlineGoogle Scholar5. HOWELLSEEGMILLER RRJE: Inflammatory response to injected sodium urate. Eighth Interim Scientific Session of the American Rheumatism Association, December, 1961. Google Scholar6. SEEGMILLERHOWELLMALAWISTA JERRSE: The inflammatory reaction to sodium urate. JAMA 180: 469, 1962. Google Scholar7. FAIRESMCCARTY JSDJ: Acute arthritis in man and dog produced by intrasynovial injection of sodium urate crystals. Clin. Res. 9: 329, 1961. Google Scholar8. FAIRESMCCARTY JSDJ: Acute arthritis in man and dog after intrasynovial injection of sodium urate crystals. Lancet 2: 682, 1962. CrossrefGoogle Scholar9. TALBOTT JH: Gout, 2nd ed. Grune & Stratton, New York, 1964, p. 195. Google Scholar10. HOWELLEANESSEEGMILLER RREDJE: X-ray diffraction studies of the tophaceous deposits in gout. Arthritis Rheum. 6: 97, 1963. CrossrefMedlineGoogle Scholar11. HAMBURGER HJ: Die Technik des Arbeitens mit Phagocyten biologischen Zwecken. Abderhalden Handbuch biologischen Arbeitsmethoden. 4: 953, 1926. Google Scholar12. BUCHANANKLINENBERGSEEGMILLER WWJRJE: The inflammatory response to injected microcrystalline monosodium urate in man. A comparison of the magnitude of the response in normal, hyperuricemic, gouty and uremic subjects. Arthritis Rheum, (in press). Google Scholar13. LIDDLESEEGMILLERLASTER LJEL: The enzymatic spectrophotometric method for determination of uric acid. J. Lab. Clin. Med. 54: 903, 1959. MedlineGoogle Scholar14. SEEGMILLERHOWELL JERR: The old and new concepts of acute gouty arthritis. Arthritis Rheum. 5: 616, 1962. CrossrefMedlineGoogle Scholar15. ROSENBLOOMSEEGMILLER FJE: An enzymatic spectrophotometric method for determination of orotic acid. J. Lab. Clin. Med. 63: 492, 1964. MedlineGoogle Scholar16. WALLACE SL: Colchicine. Clinical pharmacology in acute gouty arthritis. Amer. J. Med. 30: 439, 1961. CrossrefMedlineGoogle Scholar17. SEEGMILLER JE: Unpublished observations. Google Scholar18. KLINENBERG JR: Personal communication. Google Scholar19. SEEDSLAUGHTERLIMARZI LDPLR: Effect of colchicine on human carcinoma. Surgery 7: 696, 1940. Google Scholar20. HOWELLSEEGMILLER RRJE: Mechanism of action of colchicine. Arthritis Rheum. 5: 303, 1962. Google Scholar21. GOLDFINGERHOWELLSEEGMILLER SRRJE: Effects of colchicine on leukocyte metabolism. (Submitted). Google Scholar22. MALAWISTA SE: Sols, gels, and colchicine: a common formulation for the effects of colchicine in gouty inflammation and on the mitotic spindle. Arthritis Rheum. 7: 325, 1964. Google Scholar23. CANER JE: Colchicine inhibition of chemotactic migration of human polymorphonuclear leukocytes. Ibid., p. 297. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN E. MALAWISTA, M.D.; J. E. SEEGMILLER, M.D.Affiliations: Bethesda, MarylandFrom the Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Stephen E. Malawista, M.D., Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., New Haven 11, Conn. 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Physiological and Pharmacological AspectsPotentiation of the colchicine effect on frog melanocytes by high hydrostatic pressureAn experimental model of acute inflammation in manTHE KIDNEY IN HEPATIC DISEASE AND IN GOUT: CLINICAL AND PATHOLOGIC ASPECTSAllopurinol in the Treatment of GoutR. WAYNE RUNDLES, M.D., F.A.C.P., EARL N. METZ, M.D., H. R. SILBERMAN, M.D.Suppression of metabolic accompaniments of phagocytosis by colchicineThe action of colchicine in acute goutArthritis—The Great Crippler 1 April 1965Volume 62, Issue 4Page: 648-657KeywordsArthritisAttentionColchicineGoutInflammatory arthritisMetabolic disordersPatientsPhagocytosisRheumatic feverUric acid ePublished: 1 December 2008 Issue Published: 1 April 1965 PDF downloadLoading ...