Key result
Treatment with captopril, lisinopril, and taurine significantly decreased extracellular matrix protein expression in aging rats, with taurine reducing TGF-beta1 mRNA levels by 40%.
Why the study?
Does treatment with ACE inhibitors or taurine prevent age-related progressive renal fibrosis in rats?
Does treatment with ACE inhibitors or taurine prevent age-related progressive renal fibrosis in rats?
ACE inhibitors and taurine demonstrate a protective role against age-related progressive renal sclerosis in a rat model, likely through interactions with the TGF-beta1 pathway.
Age-related renal ECM accumulation in rats may respond to ACE inhibitors or taurine; extends prior ROS/TGF-β1 work but leaves open human translation.
Our previous studies demonstrated an increased reactive oxygen species (ROS) production, as well as transforming growth factor-beta1 (TGF-beta1) expression in the rat kidney with aging. In the present study, we examined the effect of aging on extracellular matrix (ECM) accumulation and the effects of treatment with angiotensin-converting enzyme inhibitors (captopril and lisinopril) and taurine, an antioxidant amino acid. Age-related increases in types I and IV collagen and fibronectin mRNA expression were found at 24 and 30 mo of age. In contrast, type III collagen only increased in 30-mo-old rats. Captopril-, lisinopril-, and taurine-treated animals showed a statistically significant decrease in ECM protein expression at both ages. Moreover, treatment with taurine reduced the TGF-beta1 mRNA levels in 24- and 30-mo-old rats by 40%. Taurine also completely blocked increases in type I and type IV collagen expression in mesangial cells in response to TGF-beta1. Our results demonstrate a protective role from both converting enzyme inhibitors and taurine in the age-related progressive renal sclerosis. In addition, taking into account that taurine is considered as an antioxidant amino acid, present data suggest a role for ROS in age-related progressive renal fibrosis, perhaps through interactions with the TGF-beta1 pathway.
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Cruz et al. (2000) studied Age-related progressive renal fibrosis. ACE inhibitors (captopril and lisinopril) and taurine was evaluated on Extracellular matrix (ECM) protein expression. Treatment with captopril, lisinopril, and taurine significantly decreased extracellular matrix protein expression in aging rats, with taurine reducing TGF-beta1 mRNA levels by 40%.
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