Key result
External single ring aortic annuloplasty increases post-valve velocities ~3-fold while reducing diastolic backward flow.
Why the study?
The impact of aortic annuloplasty approaches on aortic root hemodynamics was not well understood and required evaluation using combined in vivo, in vitro, and in silico methods.
Does external single ring aortic annuloplasty alter aortic root hemodynamics in a porcine-specific model?
Does external single ring aortic annuloplasty alter aortic root hemodynamics in a porcine-specific model?
The development of an animal-specific digital twin of a post-aortic annuloplasty aortic root demonstrates that the annuloplasty ring significantly alters hemodynamics, increasing systolic velocities and reducing diastolic vortical flow.
Answers are grounded in this paper and cite their sources.
Alters aortic root hemodynamics in porcine model; hypothesis-generating and should not yet change clinical practice.
• Implementation of the first animal-specific post-aortic annuloplasty aortic root model • 3D printed fabrication of resin pre- and post-aortic annuloplasty models and successful integration in flow experiments conducted in vitro • Fluid-structure interaction implementation of pre- and post-aortic annuloplasty in silico digital twins • Comparative assessment of aortic root hemodynamics pre- and post- aortic annuloplasty by velocity, vorticity, hellicity, Von Mises and wall shear stresses investigation • Proof-of-concept validation of the in silico framework against in vivo evidence Aortic annuloplasty (AA) is an innovative surgical technique for aortic root (AR) enlargement. It is performed by implanting sutures, bands, or rings, either externally or internally the AR, hereby reducing its diameter. This study evaluates the impact of AA approaches on AR hemodynamic by employing a porcine-specific workflow combining in vivo magnetic resonance imaging (MRI), in vitro experiments and in silico fluid-structure interaction (FSI) simulations investigating external single ring AA. CAD models of native and post-annuloplasty ARs were segmented from in vivo porcine MRI data and served as the basis for fabricating 3D-printed resin phantoms and implementing computational digital twins. The former were tested on a pulsatile flow-loop, whereas the latter were integrated in FSI simulations, with time-dependent boundary conditions based on the resultant experimental pressure waveforms. Additionally, a proof-of-concept validation of the in silico model against in vivo data is proposed. Computational results of the two cases were compared in terms of fluid velocity, vorticity, helicity, and wall shear stresses, providing a step towards understanding the complex interactions between the AR and blood flow dynamics. Results suggested that the presence of the ring increased the systolic jet flow and post-valve velocities (three-fold increase), reduced the backward, vortical flow during diastole (∼ 9% decrease), and induced modifications in bulk flow and wall shear stresses distribution. Furthermore, the development of an animal-specific digital twin of a post-AA AR represents a significant advancement in the field, providing a valuable tool for future research and for clinical applications to aid AA decision-making process.
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Zattoni et al. (2026) studied Aortic root enlargement / Aortic valve regurgitation (n=2). External single ring aortic annuloplasty vs. Native aortic root was evaluated on Hemodynamic parameters (fluid velocity, vorticity, helicity, wall shear stresses). External single ring aortic annuloplasty increased systolic jet flow and post-valve velocities by three-fold and reduced backward vortical flow during diastole by approximately 9% compared to the native aortic root.
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