Key result
Male sex and lower AnMin index predict diastolic annular enlargement, occurring in ~21% of patients.
Why the study?
The characteristics of aortic annulus changes in aortic regurgitation patients are poorly understood, and predictive factors among aortic valve disease have not been established.
Observational (n=107)
Effect estimate: ROC AUC 0.70 and 0.87
Systolic measurements of the aortic annulus are recommended for AR patients, as 21% of patients exhibit diastolic enlargement which could lead to prosthesis undersizing if only systolic measurements are used.
Diastolic annular assessment may reduce undersizing risk in select AR patients; leaves open whether gender- or index-guided protocols improve TAVR outcomes.
Background: The characteristics of aortic annulus changes in aortic regurgitation (AR) patients are poorly understood, and predictive factors among aortic valve disease are yet to be established. Objective: This study seeks to elucidate the pattern of annular size fluctuations across different cardiac phases in AR patients and to identify predictors for annular enlargement during either systole or diastole in aortic valve diseases. Methods: A retrospective analysis was conducted on 55 patients with severe aortic valve diseases, including 26 patients with aortic stenosis (AS) and 29 with AR, to discern the two groups' contrasting and analogous patterns of annular changes. The patient sample was expanded to 107 to investigate the factors influencing the size of the annulus during different cardiac phases. Based on our findings, patients were then divided into two groups: those with an annulus that is larger during systole (83 patients) and those where the annulus is larger during diastole (24 patients). Results: Typically, AR patients exhibit a dynamic annulus, with both perimeter and area being largest during mid-systole. These dimensions diminish progressively and then increase again in early diastole, a pattern consistent with observations in AS patients. Among 107 patients, 21% had diastolic enlargement. Systolic measurements would lead to prosthesis undersizing in 17% of these. Male gender and lower systolic annulus minimum relative to body surface area (AnMin index) were predictors of diastolic enlargement, with ROC curve areas of 0.70 and 0.87 for AR and AS, respectively. Conclusions: Systolic measurements are recommended for AR patients. Gender and the AnMin index are significant predictors, particularly potent in AS patients.
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Peng et al. (2023) conducted an observational in Severe aortic valve diseases (aortic stenosis and aortic regurgitation) (n=107). Male gender and lower systolic annulus minimum relative to body surface area (AnMin index) was evaluated on Diastolic enlargement of the aortic annulus (ROC AUC 0.70 and 0.87). Male gender and lower AnMin index predicted diastolic annular enlargement (present in 21% of patients) with ROC curve areas of 0.70 for aortic regurgitation and 0.87 for aortic stenosis.
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