Key result
Clinically identified genetic diseases were present in 2.8% (95% CI 1.5-3.8%) and radiation-induced sarcomas in 3.3% (95% CI 1.7-5.1%) of adults with soft tissue sarcomas.
Why the study?
What is the frequency of established risk factors (genetic syndromes, radiation, lymphoedema) in adults with soft tissue sarcomas?
Population
658 adult patients with soft tissue sarcomas
Design
Cohort
Authors
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Most adult soft tissue sarcomas lack classical risk factors; leaves open whether genetic predisposition exceeds prior estimates.
Observational (n=658)
What is the frequency of established risk factors (genetic syndromes, radiation, lymphoedema) in adults with soft tissue sarcomas?
Most adult soft tissue sarcomas are not related to classical clinically identified genetic diseases, previous radiation therapy, or chronic lymphoedema, though the frequency of underlying genetic syndromes may be higher than previously reported.
Penel et al. (2008) conducted an observational in Soft tissue sarcomas (n=658). Genetic syndromes, previous radiation therapy, and chronic lymphoedema was evaluated on Frequency of particular etiological factors. Clinically identified genetic diseases were present in 2.8% (95% CI 1.5-3.8%) and radiation-induced sarcomas in 3.3% (95% CI 1.7-5.1%) of adults with soft tissue sarcomas.
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