Key result
Visiting the hospital more than 48 hours after symptom onset was significantly associated with prolonged shedding of A(H1N1)pdm09 influenza virus (OR 9.0).
Observational (n=35)
No
Odds Ratio: 9 (95% CI 1.56–51.87)
p-value: p=0.01
Delayed hospital presentation and older age are associated with prolonged viral shedding in adults with A(H1N1)pdm09 influenza.
May encourage earlier evaluation in suspected influenza; leaves open effects on transmission and need for prospective trials.
SUMMARY The dynamics of influenza A viral load in respiratory samples collected from adult A(H1N1)pdm09 influenza patients were investigated. Three respiratory specimens were obtained every 2-4 days and clinical findings were recorded at the time each specimen was collected. A total of 105 serial specimens were collected from 35 patients. Viral clearance was more rapid in patients aged 15-29 years than patients aged 30-49 years (P < 0.01) or ≥ 50 years (P < 0.01). Hospitalized patients showed slow viral clearance compared to outpatients (P < 0.01). Resolution of cough and headache was correlated with viral load reduction in respiratory specimens. Viral shedding was found in 17 patients (48.6%) 5 days after symptom onset. Time to hospital visit after symptom onset was significantly correlated with prolonged viral shedding (odds ratio 9.0, 95% confidence interval 1.56-51.87, P = 0.01). These findings will contribute to infection control aspects with respect to managing patients with influenza virus infections.
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Noh et al. (2013) conducted an observational in A(H1N1)pdm09 influenza (n=35). Time to hospital visit >48 hours after symptom onset vs. Time to hospital visit ≤48 hours after symptom onset was evaluated on Prolonged viral shedding (>5 days after symptom onset) (OR 9.0, 95% CI 1.56-51.87, p=0.01). Visiting the hospital more than 48 hours after symptom onset was significantly associated with prolonged shedding of A(H1N1)pdm09 influenza virus (OR 9.0).
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