Key result
Sustained-release diltiazem and propranolol show no significant effect on plasma lipoprotein concentrations.
Why the study?
The effects of diltiazem and propranolol on plasma lipoproteins in hypertensive patients were unclear and required direct comparison in a controlled trial.
Does sustained-release diltiazem compared to propranolol affect plasma lipoprotein concentrations in mild-to-moderate hypertensive patients?
RCT (n=21)
Double-blind
randomized
Does sustained-release diltiazem compared to propranolol affect plasma lipoprotein concentrations in mild-to-moderate hypertensive patients?
Changes in plasma lipoproteins during antihypertensive treatment with diltiazem or propranolol may reflect normal intrapatient variability rather than true drug effects.
No takes yet. Share an insight, caveat, or question.
No lipoprotein changes with either agent; confirms lipid neutrality and attributes fluctuations to intrapatient variability.
Labreche et al. (1993) conducted an RCT in Mild-to-moderate hypertension (n=21). Sustained-release diltiazem vs. Propranolol was evaluated on Plasma lipoprotein concentrations (Total cholesterol, HDL, LDL, and VLDL). Sustained-release diltiazem and propranolol produced no significant changes in plasma lipoprotein concentrations compared with baseline or each other.
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