Why the study?
Does sustained-release diltiazem reduce supine blood pressure compared to propranolol in patients with mild to moderate essential hypertension?
Population
196 patients with mild to moderate essential hypertension and supine diastolic blood pressures of 95 to 114…
Comparison
Sustained-release diltiazem for 6 months, with… vs Propranolol for 6 months, with…
Design
RCT, randomized, parallel group, double-blind
Follow-up
6 months
Authors
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Either agent may be used for BP control in mild-moderate hypertension; confirms equivalence of diltiazem and propranolol in RCT.
Does sustained-release diltiazem reduce supine blood pressure compared to propranolol in patients with mild to moderate essential hypertension?
Diltiazem and propranolol are equally effective as monotherapy or in combination with hydrochlorothiazide for reducing blood pressure in mild to moderate essential hypertension.
Massie et al. (1987) studied this question.
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