What question did this study set out to answer?

The aim is to compare the effectiveness of propranolol and hydrochlorothiazide for treating initial hypertension.

October 22, 1982JAMA

Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension

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Why the study?

Does propranolol or hydrochlorothiazide better improve blood pressure control in patients with initial diastolic BP of 95 to 114 mm Hg?

Population

683 patients with initial diastolic BP in the range of 95 to 114 mm Hg

Comparison

Propranolol hydrochloride vs Hydrochlorothiazide

Design

RCT, randomly allocated, doubleblind

Follow-up

12 months

Discussion

Member takes

Implication

Supports hydrochlorothiazide over propranolol for initial BP control in moderate hypertension; reinforces thiazide preference in guidelines.

Key Points

The aim is to compare the effectiveness of propranolol and hydrochlorothiazide for treating initial hypertension.
Randomly assigned 683 patients to receive either propranolol or hydrochlorothiazide in a double-blind manner
Patients had initial diastolic blood pressure between 95 and 114 mm Hg
Long-term treatment phase lasted 12 months with focus on blood pressure control and tolerability.
Hydrochlorothiazide reduced diastolic blood pressure by —17.5 mm Hg compared to —8.3 mm Hg with propranolol (p < 0.05)
65.5% of patients on hydrochlorothiazide achieved target BP <90 mm Hg versus 52.8% on propranolol
Fewer patients on hydrochlorothiazide required treatment termination during the study.

Structured PICO

Does propranolol or hydrochlorothiazide better improve blood pressure control in patients with initial diastolic BP of 95 to 114 mm Hg?

Population

683 patients with initial diastolic BP in the range of 95 to 114 mm Hg (394 entered the long-term treatment phase)

Intervention

Propranolol hydrochloride

Comparator

Hydrochlorothiazide

Outcome

Blood pressure control (mean reductions in BP and percentage achieving goal diastolic BP < 90 mm Hg) at 12 monthssurrogate

Hydrochlorothiazide is more effective than propranolol for initial blood pressure control and achieving target diastolic BP in hypertensive patients.

Cite This Study

A 1982 study studied this question.

synapsesocial.com/papers/6a1fea83d4e6d3589704aa18 https://doi.org/10.1001/jama.1982.03330160052024

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Implication

Supports hydrochlorothiazide over propranolol for initial BP control in moderate hypertension; reinforces thiazide preference in guidelines.

Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider