What question did this study set out to answer?

To assess the short- and long-term effects of propranolol versus hydrochlorothiazide monotherapy on fasting plasma glucose levels and oral glucose tolerance in hypertensive men.

November 1, 1985Hypertension

Propranolol or hydrochlorothiazide alone for the initial treatment of hypertension. IV. Effect on plasma glucose and glucose tolerance. Veterans Administration Cooperative Study Group on Antihypertensive Agents.

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Why the study?

Does propranolol compared to hydrochlorothiazide affect plasma glucose and glucose tolerance in hypertensive men?

Population

683 hypertensive men

Comparison

Propranolol monotherapy vs Hydrochlorothiazide monotherapy

Design

RCT, randomized

Follow-up

1 year (plus 1 month post-discontinuation)

Discussion

Member takes

Implication

Supports lowest effective dosing of both agents in hypertension to limit glycemic effects; extends RCT evidence on their metabolic impact.

Key Points

To assess the short- and long-term effects of propranolol versus hydrochlorothiazide monotherapy on fasting plasma glucose levels and oral glucose tolerance in hypertensive men.
Randomized trial allocating 683 hypertensive men to initial monotherapy with either propranolol or hydrochlorothiazide.
Plasma glucose levels were evaluated at 10 weeks, 1 year, and 1 month after drug discontinuation, with a subset of 191 participants undergoing 2-hour oral glucose tolerance tests.
Both drugs increased average fasting plasma glucose by approximately 5 mg/dl at 10 weeks (p < 0.001) and 1 year (p < 0.001), though the increase persisted only in the propranolol group 1 month post-discontinuation (p < 0.01).
Hydrochlorothiazide raised 2-hour oral glucose tolerance test levels by 18.0 mg/dl at 10 weeks (p < 0.001), significantly higher than propranolol (p < 0.012); by 1 year, propranolol also increased 2-hour levels (p < 0.05) with no significant difference between arms.
Hyperglycemic effects were dose-dependent for both treatments.

Structured PICO

Does propranolol compared to hydrochlorothiazide affect plasma glucose and glucose tolerance in hypertensive men?

Population

683 hypertensive men

Intervention

Propranolol monotherapy

Comparator

Hydrochlorothiazide monotherapy

Outcome

Fasting plasma glucose level and 2-hour oral glucose tolerance test results at 10 weeks and 1 yearsurrogate

Both propranolol and hydrochlorothiazide monotherapy for hypertension increase fasting plasma glucose, suggesting both drugs should be administered at their lowest effective dosage.

Cite This Study

A 1985 study studied this question.

synapsesocial.com/papers/6a90683de02ba012352db7c6 https://doi.org/10.1161/01.hyp.7.6.1008

Topics

Hypertension management

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Implication

Supports lowest effective dosing of both agents in hypertension to limit glycemic effects; extends RCT evidence on their metabolic impact.

Propranolol or hydrochlorothiazide alone for the initial treatment of hypertension. IV. Effect on plasma glucose and glucose tolerance. Veterans Administration Cooperative Study Group on Antihypertensive Agents.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Propranolol or hydrochlorothiazide alone for the initial treatment of hypertension. IV. Effect on plasma glucose and glucose tolerance. Veterans Administration Cooperative Study Group on Antihypertensive Agents.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider