Why the study?
Does propranolol reduce arterial blood pressure in patients with moderately severe arterial hypertension?
Population
19 patients with moderately severe arterial hypertension
Comparison
Propranolol 120 mg daily, chlorthalidone 100 mg… vs Placebo
Design
RCT, double-blind
Follow-up
5 weeks per treatment
Authors
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Propranolol monotherapy lacks meaningful BP-lowering effect in moderate hypertension; challenges its first-line use and reinforces diuretic or combination regimens in RCTs.
Does propranolol reduce arterial blood pressure in patients with moderately severe arterial hypertension?
Propranolol 120 mg daily is less effective than chlorthalidone 100 mg daily for lowering blood pressure in patients with moderately severe hypertension.
Richardson et al. (1968) studied this question.