Key result
Once-daily propranolol resulted in no significant difference in blood pressures compared to three daily doses, and was well tolerated with possibly fewer vivid dreams.
Why the study?
Does once-daily propranolol compared to three-times-daily propranolol maintain blood pressure control in patients with essential hypertension?
RCT (n=26)
Does once-daily propranolol compared to three-times-daily propranolol maintain blood pressure control in patients with essential hypertension?
Answers are grounded in this paper and cite their sources.
Once-daily propranolol is as effective as three-times-daily dosing for blood pressure control in essential hypertension and may cause fewer vivid dreams.
In 26 patients with essential hypertension who were on continuous chlorthalidone therapy, 1 and 3 daily doses of propranolol were compared in a crossover study. Plasma propranolol levels and heart rates had larger daily fluctuations on single-dose therapy than on 3 times daily; plasma renin activity was more constant. There was no significant difference in blood pressures. Once-daily propranolol dosage was well tolerated and possibly gave less rise to the troublesome side effect of vivid dreaming.
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Brink et al. (1980) conducted an RCT in essential hypertension (n=26). Propranolol vs. 3 daily doses was evaluated on Blood pressures. Once-daily propranolol resulted in no significant difference in blood pressures compared to three daily doses, and was well tolerated with possibly fewer vivid dreams.
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