Key result
Isradipine reduced supine diastolic blood pressure by 10 mm Hg in 88% of patients compared to 83% with propranolol, with no significant difference between groups.
Why the study?
Does isradipine reduce blood pressure compared to propranolol in hypertensive patients inadequately controlled on hydrochlorothiazide?
Population
78 hypertensive patients with supine diastolic blood pressure >95 mm Hg while receiving ≥50 mg/d of…
Comparison
Isradipine 2.5 to 10 mg orally twice a day… vs Propranolol hydrochloride 60 to 240 mg orally…
Design
RCT, Randomized, parallel, Double-blind
Follow-up
10 weeks
Authors
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Supports isradipine as alternative to propranolol for add-on blood pressure control; confirms comparable efficacy in hydrochlorothiazide-treated hypertension.
RCT (n=78)
Double-blind
parallel
Does isradipine reduce blood pressure compared to propranolol in hypertensive patients inadequately controlled on hydrochlorothiazide?
Absolute Event Rate: 88% vs 83%
Isradipine is as effective as propranolol in reducing blood pressure when added to hydrochlorothiazide in patients with uncontrolled hypertension, though it is associated with a higher absolute frequency of adverse reactions.
L. Michael Prisant (1989) conducted an RCT in Hypertension (n=78). Isradipine vs. Propranolol hydrochloride, 60 to 240 mg orally twice a day was evaluated on Supine diastolic blood pressure reduced by 10 mm Hg. Isradipine reduced supine diastolic blood pressure by 10 mm Hg in 88% of patients compared to 83% with propranolol, with no significant difference between groups.
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