Why the study?
Does diltiazem improve thyrotoxic symptoms and hemodynamics as effectively as propranolol in patients with untreated thyrotoxicosis?
Population
6 patients with untreated thyrotoxicosis, mean age 31 years.
Comparison
Diltiazem 60 mg orally four times a day for 1… vs Propranolol 40 mg orally four times a day for 1…
Design
RCT, Randomized crossover design, Double-blind
Follow-up
1 week per treatment arm
Authors
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Diltiazem matches propranolol for thyrotoxic symptom control and hemodynamics; supports its use as alternative when beta-blockers contraindicated.
Does diltiazem improve thyrotoxic symptoms and hemodynamics as effectively as propranolol in patients with untreated thyrotoxicosis?
Diltiazem provides similar clinical and hemodynamic improvement to propranolol in thyrotoxicosis, offering a viable alternative when beta-blockers are contraindicated.
Milner et al. (1990) studied this question.
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