Key result
Prosthetic arterial grafts show a ~36% thrombosis rate over 9 months vs zero with autogenous veins.
Why the study?
The patency rates and healing characteristics of different prosthetic arterial grafts compared with autogenous veins for femoral artery bypass were not well characterized.
Do prosthetic arterial grafts have comparable patency rates to autogenous jugular veins in a canine femoral artery bypass model?
Do prosthetic arterial grafts have comparable patency rates to autogenous jugular veins in a canine femoral artery bypass model?
Autogenous veins demonstrated superior patency (0% occlusion) compared to various prosthetic grafts in a canine femoral artery bypass model, with graft thrombosis associated with hyperplastic proliferative intimal lesions.
Answers are grounded in this paper and cite their sources.
Autogenous vein outperformed synthetics in canine femoral bypass; leaves open whether modern prosthetics close the gap in human peripheral disease.
The patency rates and healing characteristics during a nine-month period of internal velour Dacron grafts, external velour Dacron grafts, and Sparks-Mandril grown grafts were compared with autogenous jugular veins when used to bypass short segments of the canine femoral artery. Graft thrombosis occurred in three of 11 external velour grafts, in six of 11 internal velour grafts, and in three of 11 Sparks-Mandril grafts, None of 33 autogenous veins occluded. Graft thrombosis was not correlated with the degree of graft healing but rather with a hyperplastic proliferative intimal lesion observed at the proximal anastomosis of the occluded grafts.
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Richard M. Green (1979) studied Femoral artery bypass (n=66). Prosthetic arterial grafts (internal velour Dacron, external velour Dacron, Sparks-Mandril) vs. Autogenous jugular veins was evaluated on Graft thrombosis. Prosthetic arterial grafts had a 36.4% thrombosis rate over 9 months, whereas none of the autogenous jugular vein grafts occluded.
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