Key result
Hypertension is linked to increased cardiac autonomic neuropathy and peripheral sensory dysfunction versus controls.
Why the study?
Typical complications of diabetes such as cardiac autonomic and peripheral sensory neuropathy may also occur in nondiabetic hypertensive patients, but this relationship is not well characterized.
Do nondiabetic and diabetic patients with hypertension have increased cardiac autonomic and peripheral sensory neuropathy compared to healthy controls?
Cross-Sectional (n=39)
Do nondiabetic and diabetic patients with hypertension have increased cardiac autonomic and peripheral sensory neuropathy compared to healthy controls?
Cardiac autonomic and peripheral sensory neuropathy, typically associated with diabetes, can also be observed in nondiabetic patients with hypertension, suggesting a role for vascular factors in neuropathy development.
Treated hypertensives showed cardiac autonomic neuropathy and sensory dysfunction irrespective of diabetes; hypothesis-generating and requires prospective confirmation before clinical consideration.
Peripheral sensory function and cardiac autonomic neuropathy were studied in 18 nondiabetic and 10 type-2 diabetic hypertensives compared with 11 healthy controls. All the patients were treated with antihypertensive drugs. Cardiac autonomic neuropathy using Ewing method was detected in all patient groups. The current perception threshold values on peroneal nerve at 250 Hz in nondiabetic group and at 250 Hz and at 5 Hz in diabetic group were found increased compared with the controls. In conclusion, so-called typical complications of diabetes can be observed in nondiabetic hypertensives also. Our data might support the essential role of vascular factors in the development of neuropathy.
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Légrády et al. (2013) conducted a cross-sectional in Hypertension with and without type-2 diabetes (n=39). Hypertension (with or without type-2 diabetes) vs. Healthy controls was evaluated on Cardiac autonomic neuropathy and current perception threshold values on peroneal nerve. Hypertension, both with and without diabetes, was associated with the presence of cardiac autonomic neuropathy and increased current perception threshold values compared to healthy controls.
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