Key result
Physical activity significantly reduces oxidative stress markers in older adults with metabolic syndrome.
Why the study?
Oxidative stress contributes to the development of metabolic syndrome in the elderly, necessitating evaluation of interventions to prevent or treat MetS.
Do physical activity, supplementation, and dietary interventions improve oxidative stress markers in elderly patients with metabolic syndrome?
Meta-Analysis
Do physical activity, supplementation, and dietary interventions improve oxidative stress markers in elderly patients with metabolic syndrome?
Physical activity, supplementation, and dietary interventions effectively improve oxidative stress markers in elderly patients with metabolic syndrome.
Answers are grounded in this paper and cite their sources.
Lifestyle interventions may lower oxidative stress markers in elderly MetS; extends evidence for physical activity, diet, and supplements on antioxidant outcomes.
Oxidative stress is a known pathogenesis in the development of chronic diseases including metabolic syndrome (MetS). Hence, interventions should be taken to prevent or treat MetS. A systematic review and meta-analysis were performed to estimate the interventions of oxidative stress in MetS among elderly. Hindawi, Google Scholar, PubMed and Science Direct were the databases used for this systematic review and meta-analysis. Furthermore, heterogeneity was observed using the I-squared (I2) statistic to determine the source of heterogeneity if the I2-value was >40%. After all the screening processes, 20 studies met the eligibility criteria and were analysed. Meta-analysis found that physical activity on MetS shows reduction in malondialdehyde (MDA) level (MD = -0.24, 95% CI (-0.43, -0.04), P = 0.02) and increased glutathione peroxidase (GPx) level (MD = 22.92, 95% CI (10.77, 35.08), P<0.001). On the other hand, supplement intervention on MetS increased the GPx level (MD = 805.51, 95% CI (123.23, 1487.80), P = 0.02). Dietary changes on MetS may decrease the MDA level (MD = -0.78, 95% CI (-1.02, -0.54), P<0.001) however, it also increases the total antioxidant capacity (TAC) level (MD = 0.16, 95% CI (0.88 to 0.24), P<0.001). Thus, this meta-analysis showed a positive effect of physical activity, supplementation and dietary intervention as a tool to decrease oxidative stress level in elderly with MetS.
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Meramat et al. (2021) conducted a meta-analysis in Metabolic syndrome. Physical activity vs. Control was evaluated on Malondialdehyde (MDA) level (MD -0.24, 95% CI -0.43, -0.04, p=0.02). Physical activity reduced malondialdehyde levels and increased glutathione peroxidase levels compared to control in elderly patients with metabolic syndrome.
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