Key result
Capsaicin triggers distinct reflex respiratory responses via vagal and sympathetic afferents.
Why the study?
The mechanisms underlying reflex respiratory responses to capsaicin stimulation of pulmonary and splanchnic receptors involving vagal and sympathetic afferents were not fully understood.
Population
Spontaneously breathing anesthetized dogs
Comparison
Capsaicin injections at right atrial, left atrial, and abdominal aorta sites with nerve manipulations
Design
Preclinical experimental study with nerve transections and pharmacologic interventions
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No immediate clinical implications; leaves open translation of dual afferent respiratory reflexes to humans.
Capsaicin-induced reflex respiratory responses in dogs are mediated by both vagal afferents in the pericardium and sympathetic afferents in the splanchnic bed.
A 1988 study studied this question. Capsaicin was evaluated on Respiratory response. Capsaicin injection elicited varying respiratory responses (tachypnoea, apnoea, hyperpnoea) mediated by vagal and sympathetic afferents in anesthetized dogs.
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