Key result
Epicardial or coronary capsaicin elicits dose-dependent cardiovascular reflexes in dogs via vagal and spinal afferents.
Population
Anaesthetised, open chest dogs
Design
Preclinical
Authors
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Does not alter clinical practice; extends evidence for dual vagal-spinal cardiac afferents in dogs but leaves human translation open.
Capsaicin-sensitive cardiac afferent neurons in dogs have both vagal and spinal sympathetic origins, mediating complex reflex circulatory changes.
Staszewska‐Woolley et al. (1986) studied this question. Capsaicin was evaluated on Blood pressure and heart rate changes. Application of capsaicin to the epicardium or coronary arteries in dogs elicited dose-related cardiovascular reflexes, indicating capsaicin-sensitive afferent neurones have vagal and spinal origins.
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