Key result
The chemerin system participates in normal reproduction and underlies the pathological mechanisms of reproductive diseases including polycystic ovary syndrome, preeclampsia, and breast cancer.
This review highlights the multifaceted role of the adipokine chemerin in reproductive health and diseases, suggesting potential future clinical applications.
May inform chemerin-targeted therapies in PCOS, preeclampsia, and breast cancer; leaves open clinical utility pending prospective validation.
As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C-C motif chemokine receptor-like 2, CCRL2). Chemerin and the cognate receptors are also expressed in the hypothalamus, pituitary gland, testis, ovary, and placenta. Accumulating studies suggest that chemerin participates in normal reproduction and underlies the pathological mechanisms of certain reproductive system diseases, including polycystic ovary syndrome (PCOS), preeclampsia, and breast cancer. Herein, we present a comprehensive review of the roles of the chemerin system in multiple reproductive processes and human reproductive diseases, with a brief discussion and perspectives on future clinical applications.
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Yu et al. (2022) conducted a review in Reproductive health and diseases (e.g., PCOS, preeclampsia, breast cancer). Chemerin system was evaluated. The chemerin system participates in normal reproduction and underlies the pathological mechanisms of reproductive diseases including polycystic ovary syndrome, preeclampsia, and breast cancer.
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