Key result
High triglycerides linked to ~5-fold higher risk of severe CAD in hypertensive patients.
Why the study?
The contribution of triglycerides to the extent of coronary artery disease in hypertensive patients remained unclear.
Are high triglyceride levels associated with a greater extent of coronary artery disease in hypertensive patients undergoing coronary angiography?
Observational (n=821)
Are high triglyceride levels associated with a greater extent of coronary artery disease in hypertensive patients undergoing coronary angiography?
Odds Ratio: 5.2 (95% CI 3.13–8.63)
High triglyceride levels (≥150 mg/dl) are strongly associated with severe coronary artery disease in hypertensive patients.
Should not yet alter practice in hypertensives; leaves open whether triglyceride reduction reduces severe CAD risk.
BACKGROUND: The contribution of triglycerides (TG) to the extent of coronary artery disease (CAD) in hypertensive patients remained unclear. METHODS: Consecutive 821 (aged 64.5+/-11.5 years, 482 males) hypertensive patients undergoing coronary angiography were included. The relationship of TG levels (<150 vs. > or =150 mg/dl) to the extent of CAD in all patients was examined by multiple logistic regression, adjusting for other CAD risk factors. In the lipid group, low levels of HDL were also adjusted. RESULTS: Higher levels of TG were found in subjects with severe CAD compared to those with no or minimal CAD. The adjusted odds ratios for high levels of TG in the severe CAD subgroup versus the no or minimal CAD subgroup were 5.20 (95% CI, 3.13 to 8.63) in all patients and 7.51 (95% CI, 3.19 to 17.65) in the lipid group. CONCLUSIONS: High levels of TG are strong clinical markers of greater extent of CAD in hypertensive subjects undergoing coronary angiography. The results may have clinical relevance for physicians in therapeutic decision making.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2008) conducted an observational in Hypertension and coronary artery disease (n=821). High triglyceride levels (≥150 mg/dl) vs. Triglyceride levels <150 mg/dl was evaluated on Severe coronary artery disease versus no or minimal coronary artery disease (OR 5.20, 95% CI 3.13 to 8.63). High triglyceride levels (≥150 mg/dL) were strongly associated with severe coronary artery disease in hypertensive patients undergoing coronary angiography (OR 5.20; 95% CI 3.13-8.63).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: