Key result
Male IBS patients exhibited increased positive connectivity of the dorsal anterior insula with the medial prefrontal cortex, whereas female IBS patients demonstrated greater negative connectivity with the precuneus.
Population
Age-matched female and male healthy subjects and patients with irritable bowel syndrome (IBS)
Comparison
Resting-state functional magnetic resonance… vs Healthy subjects and cross-sex comparisons
Design
Cross-sectional
Authors
Loading...
Sex-specific dorsal anterior insula connectivity patterns in IBS support further mechanistic studies; hypothesis-generating and should not yet alter clinical practice.
Cross-Sectional (n=96)
No
p-value: p=<0.05
Sex and diagnosis influence the intrinsic functional connectivity of the anterior insula in patients with irritable bowel syndrome.
Hong et al. (2014) conducted a cross-sectional in Irritable Bowel Syndrome (IBS) (n=96). Irritable Bowel Syndrome (IBS) and Sex vs. Healthy controls and opposite sex was evaluated on Resting-state functional connectivity of the dorsal anterior insula (daINS) (p=<0.05). Male IBS patients exhibited increased positive connectivity of the dorsal anterior insula with the medial prefrontal cortex, whereas female IBS patients demonstrated greater negative connectivity with the precuneus.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: