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An 80-year-old man had an abrupt onset of difficulty concentrating, followed by severe fatigue, insomnia, and unsteadiness. An evaluation revealed no evidence of infection, autoimmune diseases, or exposure to toxins. His cognitive function declined markedly over two months, and myoclonus and fasciculations developed. He became progressively obtunded and died.
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Johnson et al. (2005) studied this question.
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