Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly.

Figures

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  Figure 1.. ROC curve of GGT level to predict non-response to CRT. AUC = 0.65, cut-off value 55 U/L, 64% Sensitivity, 69% Specificity (95% CI: 0.56–0.74). AUC: area under the curve; CRT: cardiac resynchronization therapy; GGT: γ-glutamyltranferase; ROC: receiver operating characteristic.

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  Figure 2.. ROC curves of GGT levels in women (A) and men (B) to predict non-response to CRT. Sex-specific cut-off level for GGT were 59 U/L in women, AUC = 0.73, 70% Sensitivity, 71% Specificity (95% CI: 0.55–0.92); and 55 U/L in men, AUC = 0.62, 60% Sensitivity, 70% Specificity (95% CI: 0.51–0.73). AUC: area under the curve; CRT: cardiac resynchronization therapy; GGT: γ-glutamyltranferase; ROC: receiver operating characteristic.

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  Figure 3.. Odds ratios of the response to CRT according to different levels of serum GGT stratified by gender, age, type of cardiopathy, presence of diabetes mellitus, persistent/permanent AF, renal dysfunction, level of LVEF and frailty. AF: atrial fibrillation; CRT: cardiac resynchronization therapy; GFR: glomerular filtration rate; GGT: γ-glutamyltranferase; LVEF: left ventricular ejection fraction.

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  Figure 4.. Impact of GGT levels on hospitalizations for AF. (A): Kaplan-Meier plots showing cumulative survival without hospitalization for AF according to GGT level: 95% in patients with GGT < 55 U/L vs. 83% in patients with GGT ≥ 55 U/L, P = 0.024; and (B): ROC curve of GGT level to predict hospitalization for AF. AUC = 0.69, cut-off value 55 U/L, 79% Sensitivity, 57% Specificity (95% CI: 0.56–0.82). AF: atrial fibrillation; AUC: area under the curve; GGT: γ-glutamyltranferase; ROC: receiver operating characteristic.